Discovering NF- B

Signaling to NF - B

A firm hand on NF B: structures of the I B –NF B complex

The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

TNAP , a Novel Repressor of NF - B - inducing Kinase , Suppresses NF - B Activation

NFB-inducing kinase (NIK) has been implicated as an essential component of NFB activation. However, the regulatory mechanism of NIK signaling remains elusive. We have identified a novel NIK interacting protein, TNAP (for TRAFs and NIK-associated protein). In mammalian cells, TNAP physically interacts with NIK, TRAF2, and TRAF3 but not IKK1 or IKK2. TNAP specifically inhibits NFB activation indu...

NF- B and AP-1 Connection: Mechanism of NF- B-Dependent Regulation of AP-1 Activity